Re: [pronut-hiv] Intake level for vitamin B6 for people living with HIV/AIDS (2)

["George M. Carter" <fiar@verizon.net>]

   Hi Vivica and all--
   First,  let me reiterate that a good, potent multi is what I recommend
   and  I  hope we can look at that issue as well--and Subha, I'd love to
   hear your thoughts on it.
   Re  B6:  are  there scientific data to support the 100 mg upper limit?
   The  table  you  provide  below merely lists the suggested upper limit
   without  any  supporting  data.  It  also  notes  only  that  "Sensory
   neuropathy  has  occurred  from  high  intakes  of supplemental forms"
   without stating what those higher doses are.
   In  an  email  from Dr. Kaiser, he noted that yes, there are 260 mg of
   B6,  which  he  feels  is  a critical part of it. And indeed, I recall
   having  seen safe upper limit levels of at least 600 mg before there's
   any  risk  of  neuropathy; Jon mentioned 1,000 mg. And I believe there
   ARE data that support that contention.
   I will try to review the literature later.
   George M. Carter
  

---Vivica Kraak wrote:

     George,
     Rachel has made an excellent and defensible point.
     The  tolerable upper intake level (UL) for Vitamin B6 for adults is
     100
     mg/d according to the Food and Nutrition Board of the Institute of
     Medicine. Please see:
     [1]http://www.iom.edu/Object.File/Master/7/296/0.pdf
     The  most  observable  adverse effect from a chronic high intake of
     vitamin
     B6 - ironically - is sensory neuropathy. Even if an HIV+ person was
     taking INH, the therapeutic dose of B6 prescribed is 10-25 mg
     pyridoxine/d.
     There are so many forms of HIV-associated neuropathy that you can't
     conclude it is always nutritionally related.

References

   1. http://www.iom.edu/Object.File/Master/7/296/0.pdf